Author Topic: New Research Study Explains HOW the Sugar Trehalose Inhibits Alzheimer’s  (Read 4279 times)

Offline JC Spencer

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Over the last few years research in Universities around the world have supported evidence that the sugar trehalose inhibits protein plaque buildup that causes neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s diseases.  A new report from the Tianjin University in China explains just how trehalose is able to accomplish this remarkable event in the brain.  We learn that the trehalose molecules cluster around the peptide at a specific distance.  The intra-peptide hydrophobic interactions are weakened and the Aβ42 contacts are decreased by the trehalose.  This finding shines light on the actual molecular mechanism that has the inhibiting effect.  More research is needed.  This evidence helps point the way for better mental health and neurodegenerative research.

Here is the Abstract and supporting references.

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Molecular Dynamics Simulation of the Conformational Transition of Amyloid Peptide 42 Inhibited by Trehalose

LIU Fu-Feng, DONG Xiao-Yan, SUN Yan

Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China


The molecular mechanism of the conformational transition of amyloid peptide (Aβ) 42 inhibited by trehalose was studied using molecular dynamics simulations. It is confirmed that the conformational transition of Aβ42 is prevented by trehalose in a dose-dependent manner. In water and low-concentration trehalose (0.18 mol·L-1) solutions, Aβ42 transforms from its initial α-helix to a β-sheet. In 0.37 mol·L-1 trehalose, however, the conformational transition of Aβ42 is prevented. It is obvious that there is a hydration shell within about 0.2 nm from the closest atoms of Aβ42 on the peptide surface, which is caused by the preferential exclusion of trehalose. Trehalose molecules cluster around the peptide at a distance of 0.4 nm. In addition, the intra-peptide hydrophobic interactions are weakened and the number of long range contacts of Aβ42 is decreased by trehalose. Therefore, the hydrophobic collapse of the peptide is alleviated and the conformational transition is inhibited. The work has shed some light on the molecular mechanism of the inhibition effect for the conformational transition of Aβin the presence of trehalose. These findings are important for the rational design of a highly efficient inhibitor of Alzheimer's disease.

Keywords: Molecular dynamics simulation Alzheimer's disease Amyloid peptide Trehalose Received: 2009-12-10 Accepted: 2010-03-03 Online: 2010-04-23 Corresponding Authors: SUN Yan Email: [email protected]

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