Author Topic: The Sugar Trehalose Protects Epithelial and Endothelial Cells Effecting Dry Eye  (Read 3585 times)

Offline JC Spencer

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Comments by J. C. Spencer

“The sugar trehalose protects cells” is a claim we have made for a number of years.  But, we needed more research to support this claim.  Here is a study that shows trehalose protects the endothelial cells and the corneal epithelial cells.  Trehalose functionality in this paper deals with treating dry eye which further supports our statements for improving hydration of the cells.  Endothelial cells are a specialized type of epithelial cell which forms the inner layer of blood vessels.  Epithelial cells help to protect or enclose organs; some produce mucus or other secretions.  Certain types of epithelial cells have tiny hairs called cilia, which help remove foreign substances.  The significance of these cells is that they play a key role in angiogenesis, the development of new blood vessels from pre-existing vessels.  Angiogenesis is a multi-step process that is important for both physiological and pathological development.  During angiogenesis, endothelial cells are activated and express matrix metalloproteinases (MMPs), which degrade the vascular basement membrane.  In response to environmental cues, endothelial cells secrete MMPs and then invade through the basement membrane to form new capillary networks.

Now for the report:

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WO 1997024129 19970710



The present invention relates to a novel use of trehalose in medical treatment in the field of ophthalmology. More specifically, it relates to a pharmaceutical composition containing trehalose, which shows protecting effect on cornea and is used safely as an intraocular irrigating solution, eye drops, or eye ointment.

(The article is too long to post here and can be read at )